The Effect of Creatine Supplementation on Weight Loss and Physiological Status in Obese Laboratory Rats (Rattus norvegicus)
DOI:
https://doi.org/10.63939/heq6a713Keywords:
Obesity, Creatine, Dietary supplements, Fats, Cholesterol, Obesity diseaseAbstract
This study was conducted at the University of Basra, College of Science - Department of Biology. The study included the evaluation and comparison of the physiological and histological effects of the aqueous solution of the dietary supplement creatine on laboratory rats. The results revealed a significant decrease in weights (p < 0.05) in the group of animals treated with the T3 creatine solution, where a notable drop in weights was observed. Meanwhile, the control group (C). The results revealed a significant increase (p < 0.05) in the levels of both albumin and globulin, as well as total protein, in the animals treated with the T3 creatine solution compared to the control group. The results revealed a significant decrease (p < 0.05) in leptin levels compared to the control group C. The results revealed a significant decrease (p < 0.05) in the levels of thyroid hormones T3 and T4 in the treated animals compared to the control group C. The results revealed a significant decrease (p < 0.05) in glucose and insulin levels, as well as insulin resistance, compared to the control group C. The results revealed a significant decrease (p < 0.05) in the levels of liver enzymes AST and ALT compared to the control group C. The results revealed a significant decrease (p < 0.05) in levels of triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), and very low-density lipoproteins (VLDL) compared to the control group. Additionally, there was a significant increase (p < 0.05) in high-density lipoproteins (HDL) levels when compared to the control group.
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